Mitochondrial remodeling following fission inhibition by 15d-PGJ2 involves molecular changes in mitochondrial fusion protein OPA1
نویسندگان
چکیده
منابع مشابه
OPA1 Controls Apoptotic Cristae Remodeling Independently from Mitochondrial Fusion
Mitochondria amplify activation of caspases during apoptosis by releasing cytochrome c and other cofactors. This is accompanied by fragmentation of the organelle and remodeling of the cristae. Here we provide evidence that Optic Atrophy 1 (OPA1), a profusion dynamin-related protein of the inner mitochondrial membrane mutated in dominant optic atrophy, protects from apoptosis by preventing cytoc...
متن کاملMolecular machinery of mitochondrial fusion and fission.
Mitochondria generate energy by oxidative phosphorylation; play a crucial role in iron-sulfur cluster assembly; and participate in intermediary metabolism, calcium signaling, and apoptosis. They are bounded by a double membrane and contain 800 (yeast) to 1500 (human) different proteins. Although the vastmajorityofmitochondrial proteins are encoded in thenucleus and post-translationally imported...
متن کاملMitochondrial fission and fusion.
Mitochondria are highly dynamic cellular organelles, with the ability to change size, shape and position over the course of a few seconds. Many of these changes are related to the ability of mitochondria to undergo the highly co-ordinated processes of fission (division of a single organelle into two or more independent structures) or fusion (the opposing reaction). These actions occur simultane...
متن کاملRoles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis.
During apoptosis, the mitochondrial network fragments. Using short hairpin RNAs for RNA interference, we manipulated the expression levels of the proteins hFis1, Drp1, and Opa1 that are involved in mitochondrial fission and fusion in mammalian cells, and we characterized their functions in mitochondrial morphology and apoptosis. Down-regulation of hFis1 powerfully inhibits cell death to an exte...
متن کاملMitochondrial Dynamics Associated with Oxygen-Glucose Deprivation in Rat Primary Neuronal Cultures
Our objective was to investigate the mitochondrial dynamics following oxygen-glucose deprivation (OGD) in cultured rat cortical neurons. We documented changes in morphology, protein expression, and DNA levels in mitochondria following OGD and examined the roles of mitochondrial fission [dynamin-related protein 1 (Drp1), fission protein-1 (Fis1)] and fusion [mitofusin-1 (Mfn1), mitofusin-2 (Mfn2...
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ژورنال
عنوان ژورنال: Biochemical and Biophysical Research Communications
سال: 2010
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2010.07.108